Glutamate exerts its effects through binding to different types of neuron receptor cells, one of which is NMDA. Glutamate is an amino acid (building block for proteins, among other things) that was discovered in the late 1990s. Interestingly, glutamate is a major source of GABA, through biochemical conversion. Balance between the two contributes to our emotional and physical balance and well-being. The excitatory glutamate and the calming GABA are deeply intertwined. Other neurotransmitters inhibit this exchange, such as the main inhibitory NT, GABA. Excitatory neurotransmitters encourage the movement of exchange of messages between nerve cells-also known as neurons. They transmit chemical information between nerve cells or between nerve and muscle cells. Neurotransmitters are chemical messengers of the nervous system. Glutamate is found in most synapses (points of nerve cell connection) in the central nervous system (the brain and spinal cord). Glutamate plays a very large role in learning, cognition, and mood by enhancing creation of neural synapses (which are responsible for the transfer of NT) and increasing neural plasticity. It is the most potent and most common NT in the brain. Glutamate is an excitatory neurotransmitter (NT). Ketamine is as an NMDA (N-methyl-D-aspartate) antagonist working through the glutamate neurotransmitter system. Read on if you want a deeper understanding. The clinical understanding of how ketamine works is complex and newly understood. It actually facilitates new nerve cell growth and enables some established nerve cells to function more flexibly. The short answer: ketamine stimulates brain connectivity, builds new nerve pathways, and helps clear away old habitual patterns. Lower doses can alter one mildly and not be psychedelic but may prove beneficial for therapy as there can be a distinct lowering of defensiveness.ĭosing is decided collaboratively with your therapist. How long and how deeply one is altered is dose-related. With ketamine, the experience may last 10-30 minutes. You are in altered consciousness with classical psychedelics for 4-8 hours. Ketamine touches on the altered reality of classical psychedelics, but in a brief, transient way. ![]() They are considered "classical psychedelics" and most analogous and equivalent to medicines used in traditional religious ceremonies since early times. There was considerable research on LSD and Psilocybin (mushrooms which alter consciousness) in the US and Europe from the 1950s into the 1970s, when widespread social use of these medications led to the termination of research. Psychedelics came to the attention of the modern world through chemistry in the late 1930s with the discovery of LSD (lysergic acid diethylamide). Throughout human history, psychedelics have been used for healing and spiritual understanding. Ketamine is the ONLY psychedelic medicine that we will be utilizing at this time. We are firmly committed to staying within Virginia's and the United States’ legal and regulatory practices. ![]() Ketamine is currently the only legal psychedelic medicine in Virginia. ![]() Other medicines are classified as psychedelics, meaning they take you out of your everyday and usual experience of being in your mind-how you perceive yourself and the world. These experiences may also facilitate a shift in your life perspective and your current emotional state. These could be "transpersonal" (being outside of your usual sense of self), "mystical" (a heightened experience of or connection to god/spirit), or "out-of-body" (feeling separated from your physical body). Ketamine may bring about psychedelic (altered experience of being in your mind) effects.
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